Testosterone Replacement Therapy (TRT): What Men Need to Know

Wayne Kretschmer
Sep 11
3 min read

Updated: Oct 3

Testosterone is one of the most important hormones in a man’s body, driving energy levels, muscle growth, libido, mood, and overall well-being. But as men age, testosterone levels naturally decline, dropping by about 1% per year after the age of 30. For some, this decline goes unnoticed. For others, it causes fatigue, weight gain, brain fog, low libido, and even depression.

That’s where Testosterone Replacement Therapy (TRT) comes in. TRT is a medically supervised treatment that helps restore testosterone levels to a healthy range, improving quality of life and addressing symptoms of hormonal decline.

What Is Testosterone Replacement Therapy?

TRT involves prescribing testosterone to men with low testosterone (often called Low T). The goal is to bring testosterone levels back to an optimal range, typically between 600–1200 ng/dL, while improving mood, energy, strength, and sexual health. Unlike over-the-counter supplements, TRT is carefully monitored by a doctor to ensure safety and effectiveness.

Symptoms of Low Testosterone

Low testosterone can affect both the body and the mind. Common symptoms include:

Trouble concentrating or brain fog
Irritability, sadness, or depression (often misdiagnosed as clinical depression)
Increased body fat
Loss of muscle mass and strength
Ongoing fatigue and low energy
Reduced sex drive or erectile dysfunction (ED)

The ADAM Score Test

ADAM stands for Androgen Deficiency in the Aging Male. It’s a simple 10-question screening tool used by doctors to flag possible low testosterone. It’s not a blood test, but rather a quick questionnaire to help determine if further testing is needed.

The 10 ADAM questions:

Do you have a decrease in libido (sex drive)?
Do you lack energy?
Do you have a decrease in strength or endurance?
Have you lost height?
Have you noticed a reduced enjoyment of life?
Are you sad or grumpy?
Are your erections less strong?
Have you noticed a recent decline in your sports performance?
Do you fall asleep after dinner?
Has your work performance deteriorated recently?

If you answer Yes to questions 1 or 7, or to any three other questions, you screen positive for possible androgen deficiency and should have your testosterone tested by a doctor.

TRT Treatment Options

There are multiple ways testosterone can be delivered. The method chosen depends on lifestyle, preference, and medical history:

Injections (most common)
Creams or gels applied daily
Pellets inserted under the skin, lasting several months
Oral troches (dissolvable tablets)

Benefits of TRT

When monitored and prescribed correctly, many men report significant improvements with TRT, including:

Increased energy and motivation
Greater muscle mass and strength
Weight loss and reduced fat
Better sleep quality
Higher sex drive and improved sexual function
Sharper focus and mental clarity
Improved mood stability
Boosted confidence and self-esteem

Risks and Side Effects

TRT is not a quick fix or something to take casually. It requires ongoing medical supervision and regular bloodwork. Possible risks and side effects include:

Acne or oily skin
Increased red blood cell counts
Hair loss (if genetically prone)
Worsening of sleep apnea
Fertility issues (TRT can reduce sperm count but can be managed)
Mood changes if dosage isn’t properly adjusted

Who Should Consider TRT?

TRT isn’t right for everyone. Being tired after a late night doesn’t mean you have Low T. However, if you have persistent fatigue, low libido, depression, or brain fog, and blood tests confirm low testosterone, TRT may be a safe and effective option.

The bottom line: TRT can be life-changing—but only when done for the right reasons and under proper medical supervision. Always start with a qualified doctor, get your bloodwork done, and explore treatment options tailored to your needs.